dc.contributor.advisor | Otáhal, Jakub | |
dc.creator | Jindrová, Martina | |
dc.date.accessioned | 2017-04-19T12:23:22Z | |
dc.date.available | 2017-04-19T12:23:22Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://hdl.handle.net/20.500.11956/21716 | |
dc.description.abstract | Aim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused... | cs_CZ |
dc.description.abstract | Aim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused... | en_US |
dc.language | English | cs_CZ |
dc.language.iso | en_US | |
dc.publisher | Univerzita Karlova, Fakulta tělesné výchovy a sportu | cs_CZ |
dc.title | Effect of carbon dioxide on neurovascular coupling during cortical epileptic activity in rats. | en_US |
dc.type | diplomová práce | cs_CZ |
dcterms.created | 2010 | |
dcterms.dateAccepted | 2010-05-12 | |
dc.description.department | Fyzioterapie | cs_CZ |
dc.description.faculty | Faculty of Physical Education and Sport | en_US |
dc.description.faculty | Fakulta tělesné výchovy a sportu | cs_CZ |
dc.identifier.repId | 85141 | |
dc.title.translated | Účinky oxidu uhličitého na neurovaskulární spojení během epileptické kortikální aktivity u potkanů | cs_CZ |
dc.contributor.referee | Brožíčková, Carole | |
dc.identifier.aleph | 001380357 | |
thesis.degree.name | Mgr. | |
thesis.degree.level | navazující magisterské | cs_CZ |
thesis.degree.discipline | Fyzioterapie | cs_CZ |
thesis.degree.discipline | Physiotherapy | en_US |
thesis.degree.program | Specializace ve zdravotnictví | cs_CZ |
thesis.degree.program | Specializations in Health Service | en_US |
uk.thesis.type | diplomová práce | cs_CZ |
uk.taxonomy.organization-cs | Fakulta tělesné výchovy a sportu::Fyzioterapie | cs_CZ |
uk.faculty-name.cs | Fakulta tělesné výchovy a sportu | cs_CZ |
uk.faculty-name.en | Faculty of Physical Education and Sport | en_US |
uk.faculty-abbr.cs | FTVS | cs_CZ |
uk.degree-discipline.cs | Fyzioterapie | cs_CZ |
uk.degree-discipline.en | Physiotherapy | en_US |
uk.degree-program.cs | Specializace ve zdravotnictví | cs_CZ |
uk.degree-program.en | Specializations in Health Service | en_US |
thesis.grade.cs | Výborně | cs_CZ |
thesis.grade.en | Excellent | en_US |
uk.abstract.cs | Aim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused... | cs_CZ |
uk.abstract.en | Aim: The aim of the study is to investigate the effect of CO 2 on neurovascular coupling in response to epileptiform activity after trancallosal electric stimulation in rats. Methods: Adult albino rats (250-350g, n=6) were anaesthetized with isoflurane and epidural silver EEG electrodes were implanted and fixed into the skull over sensorimotor cortices. To measure regional cerebral blood flow (rCBF) during epileptic activity a self-made metal holder for Laser Doppler Flowmeter (LDF) probe was fixed to thinned skull with dental acrylic. To measure arterial blood pressure (BP) and arterial blood gasses a plastic catheter was implanted into the common carotid artery. After postsurgical recovery animals were placed in a recording chamber. After 20 minutes of background recording effect of CO 2 on basal BP an rCBF was tested by inflating a mixture of 10%CO 2 , 20%O 2 and 70%N 2 for 30seconds. To assess changes in neurovascular coupling a rat model for myoclonic seizures was used. Biphasic constant current suprathreshold stimulus (8Hz, 15s) was applied under normal or elevated CO 2 atmosphere. Results: Elevated CO2 led to a significant increase of both regional cerebral blood flow and blood pressure. In addition, inhalation of 10%CO2 during electrical stimulation of senzorimotor cortex (8Hz, 15s) caused... | en_US |
uk.publication.place | Praha | cs_CZ |
uk.grantor | Univerzita Karlova, Fakulta tělesné výchovy a sportu, Fyzioterapie | cs_CZ |
dc.identifier.lisID | 990013803570106986 | |