| dc.contributor.advisor | Berka, Pavel | |
| dc.creator | Dvořáková, Pavla | |
| dc.date.accessioned | 2017-04-20T17:10:10Z | |
| dc.date.available | 2017-04-20T17:10:10Z | |
| dc.date.issued | 2009 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11956/27735 | |
| dc.description.abstract | V teoretické cásti byla prehledne zpracována problematika kuže jako bariéry a problematika akcelerantu transdermální permeace, zejména Transkarbamu 12 (T12). V další cásti diplomové práce byl hodnocen akceleracní úcinek ruzných koncentrací T12 na in vitro permeaci kofeinu pres prasecí kuži plné tlouštky z oleokrému s 30 % vodné fáze. U krému s 0%; 0,3%; 0,5%; 0,7% a 1% T12 byly zjišteny hodnoty prumerných fluxu kofeinu Jr 6,29 ± 0,90 μg.cm-2.h-1; 9,13 ± 0,95 μg.cm-2.h-1; 8,71 ± 1,91 μg.cm-2.h-1; 10,20 ± 3,25 μg.cm-2.h-1 a 7,06 ± 0,81 μg.cm-2.h-1. Klícová slova: Transkarbam 12, akceleranty transdermální permeace, kofein, oleokrém | cs_CZ |
| dc.description.abstract | In theoretical part of this work, the skin barrier function and transdermal permeation enhancers (with focus on Transkarbam 12, T12) were reviewed. In following experimental part, the acceleration effect of various concentrations of Transkarbam 12 (T12) on in vitro caffeine permeation through full-thickness pig ear skin was evaluated. Caffeine was administered in oleocreams containing 30 % aqueous phase. The values of mean flux of caffeine Jr from creams containing 0%; 0,3%; 0,5%; 0,7% and 1% T12 were 6,29 ± 0,90 μg.cm-2.h-1; 9,13 ± 0,95 μg.cm-2.h-1; 8,71 ± 1,91 μg.cm 2.h-1; 10,20 ± 3,25 μg.cm-2.h-1 and 7,06 ± 0,81 μg.cm-2.h-1 respectively. Keywords: Transkarbam 12, transdermal permeation enhancers, caffeine, oleocream | en_US |
| dc.language | Čeština | cs_CZ |
| dc.language.iso | cs_CZ | |
| dc.publisher | Univerzita Karlova, Farmaceutická fakulta v Hradci Králové | cs_CZ |
| dc.title | Transkarbam 12 a transdermální průnik kofeinu z oleokrémů. 2. | cs_CZ |
| dc.type | diplomová práce | cs_CZ |
| dcterms.created | 2009 | |
| dcterms.dateAccepted | 2009-06-03 | |
| dc.description.department | Department of Pharmaceutical Technology | en_US |
| dc.description.department | Katedra farmaceutické technologie | cs_CZ |
| dc.description.faculty | Faculty of Pharmacy in Hradec Králové | en_US |
| dc.description.faculty | Farmaceutická fakulta v Hradci Králové | cs_CZ |
| dc.identifier.repId | 52063 | |
| dc.title.translated | Transkarbam 12 and caffeine transdermal permeation from oleocreams. 2. | en_US |
| dc.contributor.referee | Doležal, Pavel | |
| dc.identifier.aleph | 001132942 | |
| thesis.degree.name | Mgr. | |
| thesis.degree.level | magisterské | cs_CZ |
| thesis.degree.discipline | Farmacie | cs_CZ |
| thesis.degree.discipline | Pharmacy | en_US |
| thesis.degree.program | Farmacie | cs_CZ |
| thesis.degree.program | Pharmacy | en_US |
| uk.thesis.type | diplomová práce | cs_CZ |
| uk.taxonomy.organization-cs | Farmaceutická fakulta v Hradci Králové::Katedra farmaceutické technologie | cs_CZ |
| uk.taxonomy.organization-en | Faculty of Pharmacy in Hradec Králové::Department of Pharmaceutical Technology | en_US |
| uk.faculty-name.cs | Farmaceutická fakulta v Hradci Králové | cs_CZ |
| uk.faculty-name.en | Faculty of Pharmacy in Hradec Králové | en_US |
| uk.faculty-abbr.cs | FaF | cs_CZ |
| uk.degree-discipline.cs | Farmacie | cs_CZ |
| uk.degree-discipline.en | Pharmacy | en_US |
| uk.degree-program.cs | Farmacie | cs_CZ |
| uk.degree-program.en | Pharmacy | en_US |
| thesis.grade.cs | Výborně | cs_CZ |
| thesis.grade.en | Excellent | en_US |
| uk.abstract.cs | V teoretické cásti byla prehledne zpracována problematika kuže jako bariéry a problematika akcelerantu transdermální permeace, zejména Transkarbamu 12 (T12). V další cásti diplomové práce byl hodnocen akceleracní úcinek ruzných koncentrací T12 na in vitro permeaci kofeinu pres prasecí kuži plné tlouštky z oleokrému s 30 % vodné fáze. U krému s 0%; 0,3%; 0,5%; 0,7% a 1% T12 byly zjišteny hodnoty prumerných fluxu kofeinu Jr 6,29 ± 0,90 μg.cm-2.h-1; 9,13 ± 0,95 μg.cm-2.h-1; 8,71 ± 1,91 μg.cm-2.h-1; 10,20 ± 3,25 μg.cm-2.h-1 a 7,06 ± 0,81 μg.cm-2.h-1. Klícová slova: Transkarbam 12, akceleranty transdermální permeace, kofein, oleokrém | cs_CZ |
| uk.abstract.en | In theoretical part of this work, the skin barrier function and transdermal permeation enhancers (with focus on Transkarbam 12, T12) were reviewed. In following experimental part, the acceleration effect of various concentrations of Transkarbam 12 (T12) on in vitro caffeine permeation through full-thickness pig ear skin was evaluated. Caffeine was administered in oleocreams containing 30 % aqueous phase. The values of mean flux of caffeine Jr from creams containing 0%; 0,3%; 0,5%; 0,7% and 1% T12 were 6,29 ± 0,90 μg.cm-2.h-1; 9,13 ± 0,95 μg.cm-2.h-1; 8,71 ± 1,91 μg.cm 2.h-1; 10,20 ± 3,25 μg.cm-2.h-1 and 7,06 ± 0,81 μg.cm-2.h-1 respectively. Keywords: Transkarbam 12, transdermal permeation enhancers, caffeine, oleocream | en_US |
| uk.file-availability | V | |
| uk.publication.place | Hradec Králové | cs_CZ |
| uk.grantor | Univerzita Karlova, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie | cs_CZ |
| dc.identifier.lisID | 990011329420106986 | |
