Stanovení lisovatelnosti mannitolu a sorbitolu

Abstract

Souhrn Tato diplomova prace se zabyva parametry lisovani, drceni a kinetiky tablet. Jedna se o drtici silu, radialni pevnost, objemovou drtici silu, drahu, drtici energii, objemovou drtici energii a vztahy mezi lisovaci silou a lisovacim tlakem, drtici silou a lisovaci silou a vlivu lisovaci sily na radialni pevnost, drtici silu a objemovou drtici silu. Tyto charakteristiky byly zkoumany na tabletach připravenych z mikrokrystalicke celulosy Avicel 103 a Avicel 301, sacharosy, sorbitolu a manitolu (Perlitol). Tablety byly vylisovany při různych lisovacich tlacich a nasledně rozdrceny. Parametry a vztahy mezi nimi vychazi ze zaznamu sila - draha, ktery byl ziskan při procesu drceni. Z vysledků vyplyva, že zavislost mezi drtici silou a lisovaci silou je linearni v rozsahu od 4 do 15 kN, proto se pro dalši vypočty použily hodnoty ziskane při těchto tlacich. Parametry destrukčniho procesu pro dane hodnoty drtici sily, radialni pevnosti a objemove destrukčni energii byly nejvyšši u Avicelu 103 a dale klesaly v pořadi Avicel 301, sorbitol, pearlitol a sacharosa. Radialni pevnost klesala v pořadi sorbitol, Avicel 103, Avicel 301, pearlitol a sacharosa.

This diploma thesis is summarize the tablet's parameters such as pressing, crushing and the kinetics of the tablets. Moreover, the crushing force, tensile strenght, volume crushing force, trajectory, crushing energy, volume crushing energy and relations between compression force and compression pressure, crushing force and influence of compression force onto the tensile strenght, crushing force and volume crushing force. These characteristics have been investigated by using tablets made of microcrystalline celulosis called Avicel 103 and Avicel 301, saccharosis, sorbitole and mannitole (Pearlitole). Tablets were pressed with the using of various pressing pressures and then crushed. Parameters and relations inbetween them are followed by the force-trajectory data record, that has been acquired during the process of crushing. As the results are, the dependance among crushing and pressing forces is linear in the latitude of 4 - 15 kN, therefore for other enumerations I used the values gained during these measurements. Parameters of the destructing process for the numbers of crushing force, tensile strenght ans volume destruction energy were the highest with usage of Avicel 103 and then descending through Avicel 301, sorbitole, pearlitole and saccharose. Tensile strenght was descending in order:...