Regulation of Novel cytokines in Autoimmune Rheumatic Diseases
Regulace nových cytokinů při autoimunních revmatických onemocněních
diplomová práce (NEOBHÁJENO)
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Trvalý odkaz
http://hdl.handle.net/20.500.11956/42394Identifikátory
SIS: 120627
Kolekce
- Kvalifikační práce [20105]
Fakulta / součást
Přírodovědecká fakulta
Obor
Genetika, molekulární biologie a virologie
Katedra / ústav / klinika
Katedra genetiky a mikrobiologie
Datum obhajoby
18. 9. 2012
Nakladatel
Univerzita Karlova, Přírodovědecká fakultaJazyk
Angličtina
Známka
Neprospěl
Klíčová slova (anglicky)
Rheumatoid diseases, Cytokines,proinflammatory, Omentin1, Interleukin 21, Interleukin1, Interleukin 6, Tumor necorsis factor- joint damagesAbstruct A large number of cytokines are expressed in the feet and hands joints of patients with Rheumatoid arthritis. It is necessary to study the new cytokines which may help in prognosis and diagnosis of this autoimmune disease. Omentin1 and Interleukin 20 are the new cytokines and their expressions may have a role in the expression of proinflammatory cytokines; IL-1, IL-6 and TNFα, in different cell tissues such as synovial fibroblasts, chondrocytes, peripheral blood mononuclear cells and, sera. It is conceivable that these biomarkers may be used in biological therapies.
A large number of cytokines are expressed in the feet and hands joints of patients with Rheumatoid arthritis. It is necessary to study the new cytokines which may help in prognosis and diagnosis of this autoimmune disease. Omentin1 and Interleukin 20 are the new cytokines and their expressions may have a role in the expression of proinflammatory cytokines; IL-1, IL-6 and TNF, in different cell tissues such as synovial fibroblasts, chondrocytes, peripheral blood mononuclear cells and, sera. It is conceivable that these biomarkers may be used in biological therapies.