Determination of the compressibility of excipients used for formulation of tablets with theophylline.
diplomová práce (OBHÁJENO)
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Trvalý odkaz
http://hdl.handle.net/20.500.11956/63481Identifikátory
SIS: 145090
Kolekce
- Kvalifikační práce [6673]
Autor
Vedoucí práce
Oponent práce
Ondrejček, Pavel
Fakulta / součást
Farmaceutická fakulta v Hradci Králové
Obor
Farmacie
Katedra / ústav / klinika
Katedra farmaceutické technologie
Datum obhajoby
2. 6. 2015
Nakladatel
Univerzita Karlova, Farmaceutická fakulta v Hradci KrálovéJazyk
Angličtina
Známka
Výborně
Klíčová slova (česky)
Tablety, lisování, plnivaKlíčová slova (anglicky)
Tablets, compressing, fillers1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdenka Sklubalova, Ph.D. Student: Viktoria Kousoulidou Title of Thesis: Determination of the compressibility of excipients used for formulation of tablets with theophylline The current thesis is focused on the compressibility properties of five powders used in tablet formulation: Comprecel, Spherolac, DI-CAFOS D160, DI-CAFOS A150 as excipients and Theophylline as the active substance. The particle size, moisture content, bulk density and flowability of the powders are determined. The powders are compressed and the results are evaluated by means of the parameters of the compaction equation and the force-displacement method (compression under 5, 10, 15 kN). Then, the crushing strength of tablets prepared from each powder by the force-displacement method is measured. The average values of the crushing strength are used to calculate the tensile strength of the tablets. Best compressibility is found in Comprecel and Theophylline with tensile strength values of 1.31 MPa under 5 kN, 3.31 MPa under 10 kN, 4.75 MPa under 15 kN and 1.02 MPa under 5 kN, 2.27 MPa under 10 kN, 3.09 MPa under 15 kN, respectively.