Flow equation of granules prepared from sorbitol.

Abstract

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdenka Sklubalova, Ph.D. Student: Malek Azar Title of Thesis: Flow equation of granules prepared from sorbitol The aim of this thesis is to study the flow and compression behaviour of size fractions of the granules prepared from sorbitol by wet granulation method. The granules were classified according to their size. A bimodal distribution was observed. The polynomial relationship between angle of repose and the particle size was detected as well as between the latter and bulk density measured in a volumeter. The mass flow rate Q (g/s) through the circular orifice of a conical stainless steel hopper was measured and a mathematical model of Jones - Pilpel power regression was applied to describe the relationship between the mass flow rate and the diameter of the hopper orifice. Using parameters of the generated equation, the average precision of mass flow rate prediction of 4.29 % was detected for the granules regardless of the particle size.