Asymetricky substituované močoviny jako akceleranty transdermální permeace
Asymetrically substituted ureas as a skin permeation enhancers
rigorózní práce (OBHÁJENO)
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Trvalý odkaz
http://hdl.handle.net/20.500.11956/8409Identifikátory
SIS: 18236
Kolekce
- Kvalifikační práce [6650]
Autor
Vedoucí práce
Oponent práce
Vávrová, Kateřina
Fakulta / součást
Farmaceutická fakulta v Hradci Králové
Obor
Farmacie
Katedra / ústav / klinika
Katedra anorganické a organické chemie
Datum obhajoby
1. 2. 2007
Nakladatel
Univerzita Karlova, Farmaceutická fakulta v Hradci KrálovéJazyk
Čeština
Známka
Prospěl
PharmDr. Martin Šíma Asymetrically substituted ureas as a skin permeation enhancers ABSTRACT: Transkarbam 12 (5-(dodecyloxycarbonyl)pentylammonium-5-(dodecyloxycarbo-nyl)pentylcarbamate, T12) is a highly effective skin permeation enhancer. In this rigorous thesis, T12 analogs with urea function group replacing the ester one were synthetised, and evaluated in vitro as skin permeation enhancers on excised porcine skin, using theophiline as a model drug. The results were expressed by an enhancing ratio and compared with biological activity of T12 and its analogs from previous studies (alkane, ketone, amide, carbamate, and carbonate). Similarly to analogs from previous studies, there was a significant decrease in the enhancing potency. The results thus show that the ester group in the molecule of T12 is essential for its extraordinary effect.