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Studium prekurzorových forem SARS-CoV-2 3-CL proteázy
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2023)Date of defense: 30. 5. 2023The SARS-CoV-2 virus (Severe acute respiratory syndrome coronavirus 2), the causative agent of the disease COVID-19 (coronavirus disease 2019), is an enveloped virus with a positive RNA genome. After the binding of the ... -
Vliv chladové adaptace na aktivaci adrenergních a tyroidních signálních drah v myokardu potkana.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2021)Date of defense: 20. 5. 2021Despite advances in research and therapy, cardiovascular diseases are still the leading cause of death worldwide. A closer understanding of the endogenous protective mechanism may improve pharmacological interventions for ... -
Macromolecular avenues for the creation of bio-inspired hierarchically structured surfaces
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 26. 4. 2024Biomedical applications often rely on surface adherent architectures such as polymer brushes to prevent adverse nonspecific interactions between materials used in biomedicine and contacting biological fluids. Commonly, ... -
Magnetic nanoparticles with antibacterial properties: Synthesis, characterization and biological applications
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 26. 4. 2024In response to the escalating global threat of antibiotic resistance, innovative strategies are imperative. This thesis focuses on surface-engineered magnetic nanoparticles (MNPs) with potent antibacterial properties, ... -
KT/HAK/KUP High-affinity Transporters in Plants
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 26. 4. 2024Due to its essential role in plant metabolism and often low availability in the soil, sufficient potassium uptake and management are among the challenges plants face to survive in different environments. Since all potassium ... -
Modeling of biologically relevant lipid multilayers in the context of drug delivery
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 25. 4. 2024Understanding the topical drug delivery at basic physico-chemical and biophysical levels is still challenging. One of the main reasons is the specificity of the processes involved, depending on the delivery target. The ... -
Palaeoecological aspects and evolution of the Late Cretaceous oyster assemblages
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 25. 4. 2024The presented thesis explores the palaeoecological aspects of the evolution of the well-known fossil oyster genus Rhynchostreon Bayle, 1874, a significant representative of Cretaceous fauna. The study integrates sedimentological ... -
Vývoj hmotnostně-spektrometrických metod pro strukturní analýzu mastných kyselin a estolidů
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 23. 4. 2024(EN) This doctoral thesis summarizes the use of modern mass spectrometric methods for the structural identification of fatty acids and triacylglycerol estolides (TG-EST) and their subsequent characterization in the lipidome ... -
Development and utilization of electrochemical flow-through detectors
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 23. 4. 2024The proposed dissertation thesis deals with the development and investigation of electrochemical flow systems using both conventional and unconventional electrode materials. In the first part of this thesis, the problem ... -
Atomic fluorescence spectrometry with volatile species generation - a sensitive tool for ultra-trace elemental analysis
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 9. 5. 2024This thesis encompasses a development of innovative methodologies based on atomic fluorescence spectrometry, offering precise and sensitive determination of ultra-trace elements, such as bismuth, cadmium, and nickel. The ...