| dc.contributor.advisor | Mašek, Tomáš | |
| dc.creator | Dubská, Jitka | |
| dc.date.accessioned | 2017-04-20T12:20:38Z | |
| dc.date.available | 2017-04-20T12:20:38Z | |
| dc.date.issued | 2009 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11956/26545 | |
| dc.description.abstract | The increase of infectious chronic diseases is the main health problem of modern civilization. These diseases, which are spread both in developing as well as industrial countries, cause more than 59% of all life ends. Statistically, the most frequent infection is hepatitis C virus (HCV) infection. Incurable hepatic illnesses such as cirrhosis and hepatocellular carcinoma are the outcomes of the HCV infection and the liver transplantation is the only successful therapeutic option for the patients in industrial countries. It is estimated that about 170 million people worldwide are chronically infected with this virus. HCV is a small coated virus with single stranded RNA genome of positive polarity. Lots of research has been done since it was discovered twenty years ago but the efficient drug is still missing. There is a strong tendency to focus the research on searching for translation initiation inhibitors in last few years, because the whole life cycle of HCV, including RNA replication, new virions assembly etc., is dependent on translation products. Nowadays there is a small group of human proteins (so called ITAFs) known for up- or down-regulate HCV and other viruses translation initiation. It is believed, that this group is much more comprehensive. The aim of this diploma work was to construct yeast... | cs_CZ |
| dc.description.abstract | The increase of infectious chronic diseases is the main health problem of modern civilization. These diseases, which are spread both in developing as well as industrial countries, cause more than 59% of all life ends. Statistically, the most frequent infection is hepatitis C virus (HCV) infection. Incurable hepatic illnesses such as cirrhosis and hepatocellular carcinoma are the outcomes of the HCV infection and the liver transplantation is the only successful therapeutic option for the patients in industrial countries. It is estimated that about 170 million people worldwide are chronically infected with this virus. HCV is a small coated virus with single stranded RNA genome of positive polarity. Lots of research has been done since it was discovered twenty years ago but the efficient drug is still missing. There is a strong tendency to focus the research on searching for translation initiation inhibitors in last few years, because the whole life cycle of HCV, including RNA replication, new virions assembly etc., is dependent on translation products. Nowadays there is a small group of human proteins (so called ITAFs) known for up- or down-regulate HCV and other viruses translation initiation. It is believed, that this group is much more comprehensive. The aim of this diploma work was to construct yeast... | en_US |
| dc.language | Čeština | cs_CZ |
| dc.language.iso | cs_CZ | |
| dc.publisher | Univerzita Karlova, Přírodovědecká fakulta | cs_CZ |
| dc.title | Využití kvasinek ve vývoji nových antivirotik | cs_CZ |
| dc.type | diplomová práce | cs_CZ |
| dcterms.created | 2009 | |
| dcterms.dateAccepted | 2009-06-09 | |
| dc.description.department | Department of Genetics and Microbiology | en_US |
| dc.description.department | Katedra genetiky a mikrobiologie | cs_CZ |
| dc.description.faculty | Faculty of Science | en_US |
| dc.description.faculty | Přírodovědecká fakulta | cs_CZ |
| dc.identifier.repId | 36839 | |
| dc.title.translated | Yeast as a tool in development of new antivirals | en_US |
| dc.contributor.referee | Janderová, Blanka | |
| dc.identifier.aleph | 001220657 | |
| thesis.degree.name | Mgr. | |
| thesis.degree.level | navazující magisterské | cs_CZ |
| thesis.degree.discipline | Genetika, molekulární biologie a virologie | cs_CZ |
| thesis.degree.discipline | Genetics, Molecular Biology and Virology | en_US |
| thesis.degree.program | Biologie | cs_CZ |
| thesis.degree.program | Biology | en_US |
| uk.thesis.type | diplomová práce | cs_CZ |
| uk.taxonomy.organization-cs | Přírodovědecká fakulta::Katedra genetiky a mikrobiologie | cs_CZ |
| uk.taxonomy.organization-en | Faculty of Science::Department of Genetics and Microbiology | en_US |
| uk.faculty-name.cs | Přírodovědecká fakulta | cs_CZ |
| uk.faculty-name.en | Faculty of Science | en_US |
| uk.faculty-abbr.cs | PřF | cs_CZ |
| uk.degree-discipline.cs | Genetika, molekulární biologie a virologie | cs_CZ |
| uk.degree-discipline.en | Genetics, Molecular Biology and Virology | en_US |
| uk.degree-program.cs | Biologie | cs_CZ |
| uk.degree-program.en | Biology | en_US |
| thesis.grade.cs | Výborně | cs_CZ |
| thesis.grade.en | Excellent | en_US |
| uk.abstract.cs | The increase of infectious chronic diseases is the main health problem of modern civilization. These diseases, which are spread both in developing as well as industrial countries, cause more than 59% of all life ends. Statistically, the most frequent infection is hepatitis C virus (HCV) infection. Incurable hepatic illnesses such as cirrhosis and hepatocellular carcinoma are the outcomes of the HCV infection and the liver transplantation is the only successful therapeutic option for the patients in industrial countries. It is estimated that about 170 million people worldwide are chronically infected with this virus. HCV is a small coated virus with single stranded RNA genome of positive polarity. Lots of research has been done since it was discovered twenty years ago but the efficient drug is still missing. There is a strong tendency to focus the research on searching for translation initiation inhibitors in last few years, because the whole life cycle of HCV, including RNA replication, new virions assembly etc., is dependent on translation products. Nowadays there is a small group of human proteins (so called ITAFs) known for up- or down-regulate HCV and other viruses translation initiation. It is believed, that this group is much more comprehensive. The aim of this diploma work was to construct yeast... | cs_CZ |
| uk.abstract.en | The increase of infectious chronic diseases is the main health problem of modern civilization. These diseases, which are spread both in developing as well as industrial countries, cause more than 59% of all life ends. Statistically, the most frequent infection is hepatitis C virus (HCV) infection. Incurable hepatic illnesses such as cirrhosis and hepatocellular carcinoma are the outcomes of the HCV infection and the liver transplantation is the only successful therapeutic option for the patients in industrial countries. It is estimated that about 170 million people worldwide are chronically infected with this virus. HCV is a small coated virus with single stranded RNA genome of positive polarity. Lots of research has been done since it was discovered twenty years ago but the efficient drug is still missing. There is a strong tendency to focus the research on searching for translation initiation inhibitors in last few years, because the whole life cycle of HCV, including RNA replication, new virions assembly etc., is dependent on translation products. Nowadays there is a small group of human proteins (so called ITAFs) known for up- or down-regulate HCV and other viruses translation initiation. It is believed, that this group is much more comprehensive. The aim of this diploma work was to construct yeast... | en_US |
| uk.file-availability | V | |
| uk.publication.place | Praha | cs_CZ |
| uk.grantor | Univerzita Karlova, Přírodovědecká fakulta, Katedra genetiky a mikrobiologie | cs_CZ |
| dc.identifier.lisID | 990012206570106986 | |
