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Zobrazují se záznamy 1-10 z 19596
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The importance of different sources and sequencing protocols in increasing the accuracy of NGS analysis in diagnostic applications
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 28. 6. 20241 ABSTRACT Continued advances in next-generation sequencing (NGS) technology, such as capacity, speed, and reduced cost per sequenced base, revolutionize personalized medicine and bring genomics into routine clinical ... -
Functional assessment of Bcl-2 family proteins in mitochondrial metabolism and beyond
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024(CZ) Od jejich prvotní identifikace v háďátku C. elegans a také v lidských buňkách před více než 30 lety jsou proteiny z rodiny Bcl-2 spojovány s indukcí, regulací a potlačením mitochondriální apoptotické signalizace, ale ... -
Effect of obesity and metabolic complications on molecular characteristics of bone marrow skeletal stem cells in relation to bone and adipose tissue metabolism
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024Obesity and diabetes are metabolic complications associated with higher accumulation of fat in periphery and bones leading to higher fracture risk. Several approaches have been introduced in the treatment of obesity and ... -
Tectonic pattern and thermochronology of the late- to post-Variscan events in the southwestern Moldanubian Zone (Bohemian Massif)
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024The southwestern part of the Moldanubian Zone including southern flank of the Western Moldanubian Unit, Bavarian Unit and "Transitional Zone" located in between reveal a complex tectonic history as the result of late-orogenic ... -
Linking transcriptional regulation of lipid metabolism with catastrophic mitosis in fission yeast
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024Linking regulation of lipid metabolism with nuclear division has recently become a thoroughly investigated phenomenon. It has been shown that an undisturbed lipid metabolism is required for proper mitotic division from ... -
Metamorphism of gabbroic rocks of Teplá-Barrandien Unit
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024In the thesis I focuse on petrographic, geochronological and geochemical characterization of gabbroic rocks to provide constrains on the Cambro-Ordovician and Variscan evolution of the Teplá-Barrandian Unit in Bohemian ... -
Processes Driving Pollen Transfer in Generalised Pollination Systems
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 25. 6. 2024Sexual reproduction of most plant species in the world depends on pollen transfer mediated by animal pollinators. However, pollen transfer is challenging and inefficient due to conflict- ing interests between plants and ... -
Advancing efforts to improve sanitation conditions: insights from India
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 24. 6. 2024Inadequate sanitation is a significant global challenge, impacting the lives of billions of people. It has serious implications for human health and impedes progress towards development targets. Among the countries most ... -
Factors influencing sanitation conditions in developing countries: insights from Ethiopia and Cambodia
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 24. 6. 2024Hygienic sanitation - the safe disposal and management of human excreta - is central to public health and has multiple non-health benefits. While its importance is recognised in global and national strategies, there remains ... -
Synthesis of 7-aryl-7-deazapurines as potential inhibitors of MARK4
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 13. 7. 2021