Kvalifikační práce
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Zobrazují se záznamy 1-20 z 19596
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The importance of different sources and sequencing protocols in increasing the accuracy of NGS analysis in diagnostic applications
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 28. 6. 20241 ABSTRACT Continued advances in next-generation sequencing (NGS) technology, such as capacity, speed, and reduced cost per sequenced base, revolutionize personalized medicine and bring genomics into routine clinical ... -
Functional assessment of Bcl-2 family proteins in mitochondrial metabolism and beyond
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024(CZ) Od jejich prvotní identifikace v háďátku C. elegans a také v lidských buňkách před více než 30 lety jsou proteiny z rodiny Bcl-2 spojovány s indukcí, regulací a potlačením mitochondriální apoptotické signalizace, ale ... -
Effect of obesity and metabolic complications on molecular characteristics of bone marrow skeletal stem cells in relation to bone and adipose tissue metabolism
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024Obesity and diabetes are metabolic complications associated with higher accumulation of fat in periphery and bones leading to higher fracture risk. Several approaches have been introduced in the treatment of obesity and ... -
Tectonic pattern and thermochronology of the late- to post-Variscan events in the southwestern Moldanubian Zone (Bohemian Massif)
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024The southwestern part of the Moldanubian Zone including southern flank of the Western Moldanubian Unit, Bavarian Unit and "Transitional Zone" located in between reveal a complex tectonic history as the result of late-orogenic ... -
Linking transcriptional regulation of lipid metabolism with catastrophic mitosis in fission yeast
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024Linking regulation of lipid metabolism with nuclear division has recently become a thoroughly investigated phenomenon. It has been shown that an undisturbed lipid metabolism is required for proper mitotic division from ... -
Metamorphism of gabbroic rocks of Teplá-Barrandien Unit
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 27. 6. 2024In the thesis I focuse on petrographic, geochronological and geochemical characterization of gabbroic rocks to provide constrains on the Cambro-Ordovician and Variscan evolution of the Teplá-Barrandian Unit in Bohemian ... -
Processes Driving Pollen Transfer in Generalised Pollination Systems
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 25. 6. 2024Sexual reproduction of most plant species in the world depends on pollen transfer mediated by animal pollinators. However, pollen transfer is challenging and inefficient due to conflict- ing interests between plants and ... -
Advancing efforts to improve sanitation conditions: insights from India
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 24. 6. 2024Inadequate sanitation is a significant global challenge, impacting the lives of billions of people. It has serious implications for human health and impedes progress towards development targets. Among the countries most ... -
Factors influencing sanitation conditions in developing countries: insights from Ethiopia and Cambodia
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 24. 6. 2024Hygienic sanitation - the safe disposal and management of human excreta - is central to public health and has multiple non-health benefits. While its importance is recognised in global and national strategies, there remains ... -
Synthesis of 7-aryl-7-deazapurines as potential inhibitors of MARK4
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 13. 7. 2021 -
Use of ionic liquids for preparation of epoxy materials
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 21. 6. 2024Epoxy resins represent an important category of thermosets widely as coatings, electronic encapsulants, matrices for composites, etc., due to their beneficial properties, such as strong adhesion, high chemical and electrical ... -
Fotoaktivní chlorofylové nanočástice
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 12. 7. 2021Photoactive sulfonated and non-sulfonated polystyrene nanoparticles (NPs) with encapsulated THF extract from spinach (Spinacia oleracea) were prepared. The preparation of NPs is based on a simple nanoprecipitation method ... -
Vliv nových derivátů chinazolinu na signální dráhy muskarinových receptorů
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 12. 7. 2021The M2 and M3 subtypes of the muscarinic receptors are involved in smooth muscle contraction in the airways and lungs. Excessive activation of muscarinic receptors is associated with serious diseases such as asthma or ... -
The characterization of Pseudomonas syringae biofilm and its interaction with antibacterial agents - biophysical approaches
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 20. 6. 20244 Abstract The objectives of this thesis are the application of Attenuated Total Reflectance Fourier Transform Infrared (ATR FT-IR) spectroscopy for the analysis of Pseudomonas syringae biofilms grown in a flow cell and ... -
Modulation of nociceptive signalling on a spinal cord level under normal and pathological conditions
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 20. 6. 2024Present pain therapies are often insufficient and poorly managed, mainly for neuropathic pain treatment. In the past years, research has provided a body of evidence on the association of nerve injury and inflammation with ... -
Role of interaction between circadian and immune system in development of obesity and type 2 diabetes mellitus
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 20. 6. 2024Disruptions within the circadian, metabolic, and immune systems contribute to the onset of metabolic illnesses, including type 2 diabetes. This doctoral thesis aimed to examine the mutual interactions between these three ... -
Makrofágy selektivně rozpoznávají mechanicky způsobenou smrt melanomových buněk a spouštějí produkci CXCL10
Výsledek obhajoby: NEOBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 4. 6. 2024Melanoma represents a significant and often fatal form of cancer, with metastasis being a primary cause of cancer-related deaths. Immunotherapy aims to stimulate the immune system to eliminate tumors, but even when used ... -
Epitranscriptomics and cardioprotective interventions
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 20. 6. 20241 Ischemic heart disease stands as the foremost global cause of mortality. Myocardial ischemia results in damage to cardiomyocytes which can further lead to impaired heart function. However, the extent of ischemic injury ... -
Linking Proteomes to Phenotypic Traits
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 19. 6. 2024Proteins, as the main functional molecules of the cell, play a critical role in shaping phenotypic traits. This thesis investigates the application of proteomics data, obtained via LC-MS/MS, to understand the link be- tween ... -
Bioinformatické prístupy k vyhodnoteniu frekvenčných populačných dát založených na sekvenčných polymorfizmoch DNA
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 19. 6. 2024This thesis focuses on the problem of efficient management of data useful in DNA analysis, specifically data obtained from short tandem repeats in human DNA, which are of key importance in forensic analysis for the ...