1 ABSTRACT Continued advances in next-generation sequencing (NGS) technology, such as capacity, speed, and reduced cost per sequenced base, revolutionize personalized medicine and bring genomics into routine clinical ...

Obesity and diabetes are metabolic complications associated with higher accumulation of fat in periphery and bones leading to higher fracture risk. Several approaches have been introduced in the treatment of obesity and ...

Linking regulation of lipid metabolism with nuclear division has recently become a thoroughly investigated phenomenon. It has been shown that an undisturbed lipid metabolism is required for proper mitotic division from ...

Sexual reproduction of most plant species in the world depends on pollen transfer mediated by animal pollinators. However, pollen transfer is challenging and inefficient due to conflict- ing interests between plants and ...

Hygienic sanitation - the safe disposal and management of human excreta - is central to public health and has multiple non-health benefits. While its importance is recognised in global and national strategies, there remains ...

Epoxy resins represent an important category of thermosets widely as coatings, electronic encapsulants, matrices for composites, etc., due to their beneficial properties, such as strong adhesion, high chemical and electrical ...

The M2 and M3 subtypes of the muscarinic receptors are involved in smooth muscle contraction in the airways and lungs. Excessive activation of muscarinic receptors is associated with serious diseases such as asthma or ...

Present pain therapies are often insufficient and poorly managed, mainly for neuropathic pain treatment. In the past years, research has provided a body of evidence on the association of nerve injury and inflammation with ...

Melanoma represents a significant and often fatal form of cancer, with metastasis being a primary cause of cancer-related deaths. Immunotherapy aims to stimulate the immune system to eliminate tumors, but even when used ...

Proteins, as the main functional molecules of the cell, play a critical role in shaping phenotypic traits. This thesis investigates the application of proteomics data, obtained via LC-MS/MS, to understand the link be- tween ...

Sequencing of DNA from microbial communities enables, besides taxo- nomic profilling, study of intrapopulation genetic variability. Its description is a result of a computational analysis of sequencing data. This thesis ...

Optogenetics is an increasingly popular neuronal stimulation technique used for study- ing neural circuits and controlling brain activity. However, when applied without suffi- cient knowledge, it can cause unintentional ...

Methods for measuring the similarity of mass spectra and the structures of small molecules are crucial for advancements in medicinal chemistry, pharmacology, and metabolomics. One commonly used method for comparing the ...

The evaluation of protein-ligand binding site similarity is crucial in many fields, from drug repurposing trials to evolutionary studies. Current state-of-the- art methods achieve good results on the benchmarking datasets. ...

A key task of translation initiation is to select a proper start codon. The start codon defines not only the position from which the protein translation is initiated but also the reading frame in which the protein sequence ...

Harmful substances polluting the environment, including ionizing radiation, and an unhealthy lifestyle are responsible for the increased incidence of cancer. The projected outlook for the next ten to twenty years suggests ...

Cystic fibrosis (CF) is an autosomal recessive disease affecting mainly the lungs, but also other organs including the liver, pancreas and reproductive organs. In the affected organs, there is a build-up of thick sputum ...

Terpenoids are natural compounds, which can be found in the form of tens of thousands diverse molecules in all forms of life. Terpenoids are mostly represented in plants, microorganisms,and animals. It should not be a ...

Coupled binuclear copper (CBC) enzymes is an important family of redox active metalloenzymes. They catalyze various chemical transformations, typically oxidation reactions. Using hybrid quantum and molecular mechanical ...

Uropathogenic bacteria Escherichia coli are the primary cause of urinary tract infections. One of the virulence factors of these bacteria is α-hemolysin (HlyA), a protein belonging to the cytolytic RTX (Repeats in ToXin) ...

The human immunoreceptor CD47, also designated <Integrin Associated Protein= is a novel therapeutic target for cancer treatment. When bound to one of its ligands, a protein found on the surface of immune cells, SIRP, the ...

This Bachelor thesis deals with the characterization of curcumin nanocrystals using capillary electrophoresis with UV-VIS and laser-induced fluorescence (LIF) detection. Curcumin is a natural polyphenolic substance with ...

This bachelor thesis explores various methods for neurosteroid prodrugs synthesis. The thesis aims to optimize the physicochemical and metabolic properties of neurosteroids to facilitate their transport across membranes, ...

The subject of this work is the preparation of multiple chiral triazole-derived conjugate acids of N-heterocyclic carbenes (NHC), a class of covalent organocatalysts used in many stereoselective transformations. The NHC ...

4 Abstract This bachelor work aims to synthesize the natural product selaginpulvilin X using a six-step synthetic route. Subsequently, the spectra of the synthesized compound were compared with the spectra of the previously ...

Phytoextraction is an example of a method of removal of chemical pollutants from the environment. The objective of this thesis was the possibility of the removal of selected pharmaceuticals and one pharmaceutical metabolite ...

Cancerous diseases causedby malignant transformationof B-lymphocytes are characterized by increased expression of surface marker 20 (CD20, cluster of differentiation 20). Traditionally, the treatment of this disease targets ...

Arsenic and phosphorus are chemical analogues, and it is proposed that they have similar chemical behaviors in environmental systems. To gain a better understanding of the geochemical processes that control the mobility ...

The diploma thesis, titled "Development of Critical Thinking in Secondary School Chemistry Teaching," presents a literary research about its key components. These include the definition of critical thinking, its significance, ...

Heavy metals can enter the ecosystem, among other forms, as divalent cations in the waste waters from industrial plants. One way of eliminating the ions from the waste waters is their absorption by polyelectrolyte hydrogels. ...

Microscopes are a common tool in science education, used to demonstrate phenomena that are not visible to the naked eye. They are most commonly encountered in the teaching of biology, but could also be used in the teaching ...

Complexes of metal ions with derivatives of 1,4,7,10-tetraazacyclododecane (cyclen) are used in various applications, such as contrast agents for magnetic resonance imaging (MRI). The structure of ligands affects the ...

Molecular simulations are capable of reproducing and predicting the behavior of real systems using a simplified model. Over the past 70 years, thanks to the rapid development of computers, this method has become an important ...

In this work, new materials based on dynamic polymer networks, also called vitrimers, were developed. These polymer networks have been developed from previously unused materials based on renewable raw materials, to maximize ...

Bakalářská práce Autor: Karolína Gálová Využití školního chromatografu GC-mini pro stanovení methanolu vedle ethanolu ve školní praxi Abstrakt - anglický jazyk The main topic of this work is to investigate the possibilities ...

Vitamins are a topic that is discussed throughout various fields of human knowledge. They are especially important because they cannot be synthesized by the human body and are needed for the proper function of the body. ...

The main objective of the work was to determine the extent to which the rocks forming the outcrops in the area between the Úštěcký and Košátecký Creek basins are subject to decay and karstification. This was studied by ...

(English) Tumor suppressors genes are capable of repressing the growth of neoplastic cells; therefore, their inactivation is an important hallmark of cancer. The novel tumor suppressor Serine beta-lactamase-like protein ...

Impact of leisure and social activites on quality of life among erderly in Europe - SHARE data analysis Abstract Due to demographic aging, the quality of life of an increasing proportion of seniors is becoming more important ...

The issue of pharmaceutical accumulation in the environment is a pressing concern today. Annually, the consumption and misuse of pharmaceuticals increase, with a significant portion ultimately being discharged into wastewater. ...