From Monomeric to Dendrimeric MRI Contrast Agents

Abstract

4, Conclueione To conclude, in my Thesis I found that ligands with phosphorus acid ped- a]11 alm substituting carboxylate in DOTA structure are endowéd with several Íavor- able features like a water residence liťetime optimal for a preparation of high- relaxivity covalent conjugates' Importantly, these promising p'óp.'ti.. were proved to persist even after the conjugation as was demonstrated ón u iy.."t.ical áitopic model compound for the first time. Imporlantly, the folrowing study of row- ge.nelatlon PAMAM conjugate proved that, unlike most oťthe published studies, trre rela:livity of these macromolecular systems ísnot exchang.-li.it"d. This has al. lowed meto investigate in detaíl the limiting effects on the iela;rivity of the internal ro^tation of the complex in the conjugates. In addition' I shown that tňe local mottons ofthe dendrimer backbone and ofthe conjugated complexes can be slowed down by a- formatíon of supramolecular adducts with cationic polyaminoacids. Also, I was able to quantitatively evaluate the effects of the local motíons and to effectively reduce them. As a result, the efficacy of these systems as relaxation agents is the highest so far reported for this class of compounds that can find a varieň of poten- tial biomedical/bioinorganic applications. For the close future, we plan in...

4, Conclueione To conclude, in my Thesis I found that ligands with phosphorus acid ped- a]11 alm substituting carboxylate in DOTA structure are endowéd with several Íavor- able features like a water residence liťetime optimal for a preparation of high- relaxivity covalent conjugates' Importantly, these promising p'óp.'ti.. were proved to persist even after the conjugation as was demonstrated ón u iy.."t.ical áitopic model compound for the first time. Imporlantly, the folrowing study of row- ge.nelatlon PAMAM conjugate proved that, unlike most oťthe published studies, trre rela:livity of these macromolecular systems ísnot exchang.-li.it"d. This has al. lowed meto investigate in detaíl the limiting effects on the iela;rivity of the internal ro^tation of the complex in the conjugates. In addition' I shown that tňe local mottons ofthe dendrimer backbone and ofthe conjugated complexes can be slowed down by a- formatíon of supramolecular adducts with cationic polyaminoacids. Also, I was able to quantitatively evaluate the effects of the local motíons and to effectively reduce them. As a result, the efficacy of these systems as relaxation agents is the highest so far reported for this class of compounds that can find a varieň of poten- tial biomedical/bioinorganic applications. For the close future, we plan in...