Aim: This disertation study was divided into two main topics, clinical trial and biomechanical experiment. The aim of clinical part was to evaluate and compare clinical outcomes after ACL reconstruction using two main types ...

Primary ciliary dyskinesia (PCD) is a rare but underdiagnosed genetic disease. This innate disorder of motile cilia causes a non-functional mucociliary clearance which is the main reason for a clinical picture of recurrent ...

Summary: Bacteria from Burkholderia cepacia complex (Bcc) and bacteria Pseudomonas aeruginosa belong among the most serious pathogens causing lung infections in patients with cystic fibrosis (CF). These bacteria are highly ...

Úvod: Psoriáza je chronické zánětlivé kožní onemocnění, které se vyskytuje cca u 2-5% populace. Je asociována s řadou komorbidit, které zhoršují kvalitu života psoriatiků a negativně ovlivňují jejich morbiditu a mortalitu. ...

Cancer development and progression vary depending on tumor type, localization, invasion, immunogenicity and the ability of immune system to become activated. There are frequent interactions between tumor cells and immune ...

The placenta and the lungs are the only organs that perform a function of blood oxygenation and have a common characteristic - vasoconstriction in response to acute hypoxia. Thus the reaction is in an opposite manner than ...

Among the protein molecules which are able to recognize and transform extracellular signals, belong the superfamily of G-protein coupled receptors (GPCR). These receptors mostly signalling through activation of effectors ...

Majority of medical decisions are based on results of diagnostic tests that help to differentiate normal from abnormal. The choice of appropriate test and its intepretation are neccessary steps for correct diagnosis and ...

The aim of this study was to reveal the presence of Helicobacter pylori (HP) in the Waldeyer's lymphatic ring of the childrens and adults and its possible link with extra- oesophageal reflux detected by using a multichannel ...

Utilization of biocompatible hydrogels based on 2-hydroxyethylmethacrylate to bridge the spinal cord lesion MUDr. Petr Lesný Biocompatible hydrogels based on copolymers of 2-hydroxyethylmethacrylate are suitable for ...

Background Bronchopulmonary malformations (BPMs) consists of a broad spectrum of developmental abnormalities, ranging from abnormal lung with normal vasculature to abnormal vasculature with normal lungs and lesions with ...

Cortical glial cells contain both ionotropic and metabotropic glutamate receptors. Despite several efforts, a comprehensive analysis of the entire family of glutamate receptors and their subunits present in glial cells is ...

Aims. The main goal was to describe interneuronal population expressing calcium binding proteins calretinin (CR) and parvalbumin (PV) in the perirhinal (PRC) and retrosplenial (RSC) cortex of the rat. These two cortical ...

The receptor for advanced glycation end products (RAGE), soluble RAGE (sRAGE) and its ligands are involved in the pathogenesis of cancer. Glyoxalase I (GLO1) is an enzyme which detoxifies advanced glycation end product ...

This dissertation concerns with characterization of binding sites for calcium binding protein S100A1 and phosphatidylinositol phosphates on intracellular regions of transient receptor potential channels (TRPs), particular ...

Currently used xenogeneic biological heart valves have several limitations in clinical practice. The main problem is the development of degenerative changes leading to valve failure. Re-surgery is required in approximately ...

- 1 - SUMMARY: The topic of this study was the association between proteinuria and graft survival after renal transplantation in children. In the first part of this study all 91 children transplanted in the Transplant ...

The work was focused on detailed analysis of patients with rare genomic and gene variants. We studied the impact of these variants on the phenotype of the patients. As the majority of our patients, both syndromic and ...

Changes of Nitric Oxide Synthase Isoforms in Experimental Hypertension and Metabolic Syndrome: Genetic and Molecular Biological Aspects Arterial hypertension (HT) together with some metabolic disorders, which are called ...

A study of the metabolism of skeletal muscle using the techniques of MR spectroscopy and MR imaging Powered by TCPDF (www.tcpdf.org)

The relationship between autoimmunity and cytokines in clinical aspects of diabetes mellitus type 1 Powered by TCPDF (www.tcpdf.org)

We evaluated the relative frequency of each mode of inheritance in the large group of CMT fam i1ies gathered in the DNA laboratory of the Dept. of Child Neurology of the 2nd Medica! School (including famiJies wi th already ...

This thesi s is eoneerned with the deteetion of posttranslational modifieation of proteins. These proteins are identified using liquid ehromatography and eapillary eleetrophoresis, their eoupling and eoupling to mass ...

lntroduction: lnvasive meningococcal disease continues to be a life-threatening condition. Rapid diagnosis is important for the administration of appropriate treatment. Our study focuses on evaluation of importance of PCR ...

It is very difficult to diagnose bronchial asthma in early childhood. Starting of preventative anti-inflammatory treatment is often delayed due to the high prevalence of acute episodes of bronchial obstructions in very ...

- Experimental pulmonary embolism, pathophysiological aspects MUDr. Roman Mizera Theoretical part of the thesis deals with mechanisms of pulmonary hypertension after pulmonary embolism (PE) and summarizes the knowledge of ...

Předkládaná dizertační práce se zabývá objektivizací neurologického nálezu u pacientů s hereditární ataxií pomocí posturografického vyšetření na baropodometrické, multisenzorické plošině. Výsledky prokázaly, že posturografické ...

SUMMARY: Metabolic acidosis (MAC) is a constant symptom of chronic kidney diesease (CKD) in advanced stages. The Siggaard-Andersen analysis is a traditional method of acid-base balance (ABB) assessment, assessing the ...

N-methyl-D-aspartate (NMDA) receptors are a subtype of ionotropic glutamate receptors, which mediate fast synaptic transmission in the vertebrate central nervous system and play a key role in synaptic plasticity. NMDA ...