A component of the innate immune system is the multifunctional protein cGAS (cyclic GMP-AMP synthase), which is primarily known for its role as a cytosolic DNA sensor. It detects pathogenic as well as self DNA that has ...

Proper spindle assembly during meiosis of mammalian oocytes ensures accurate chromosome segregation, thus preventing embryonic aneuploidy. Mammalian embryos, especially human embryos, show an increased frequency of aneuploidy, ...

Heterotrimeric G-proteins act as signal transducers in all eukaryote cells. They transduce and amplify extracellular signals sensed by integral membrane receptors to various downstream intracellular effectors. As the name ...

5 Abstract This bachelor work deals with preparation of enantiomerically enriched BINOL-derived phosphoric acids, which are used as catalysts in various asymmetric transformations. The main synthetical approach was carried ...

Axon guidance is crucial for neural development, relying on guidance cues and cytoskeletal rearrangements. Semaphorins, important guidance cues, signal through plexin receptors to influence growth cone navigation. Upon ...

This bachelor thesis focuses on baseflow as one of the components contributing to the total outflow, which is determined in hydrogeology for individual basins and other balance areas. In the literature review part, the ...

This bachelor's thesis primarily deals with the analysis of the factors of electoral support for the Pirates and STAN in the 2017 parliamentary elections and PirSTAN in 2021, supplemented by the analysis of the spatial ...

The thesis examines the detection of the climate phenomenon white dzud using optical satellite data. White dzud is the climate phenomenon causing increased livestock mortality. To create the index were used free available ...

This diploma thesis provides a complex evaluation of the hydrogeological situation in the Pňovice water supply area. The water supply area is partly located in a riparian forest. It is essential for riparian forests that ...

Phytoextraction of psychopharmaceuticals is an important model for studying contamination of food chains and its impact on ecosystems. These substances, often excreted in wastewater, can be absorbed by plants, leading to ...

Nurses in Czechia from a (geo)demographic perspective Abstract The aim of this thesis is to analyse nurses in the Czech healthcare system from demographic and geographic perspectives. The thesis focuses not only on the ...

The thesis deals with the study of hydrogeological and hydrochemical characteristics of the area of Hradčany and Petřín. The main objective was to create a comprehensive document summarizing the piecemeal knowledge of the ...

Left-rightasymmetryof epithalamus is widespread across vertebratespecies andits form is established during embryonic development. The asymmetry involves not only morphology and differential neuronal connectivity, but also ...

This thesis focuses on the characterization of immune cells and their interactions with tumor tissue. It discusses whether these cells represent an effective tool in the elimination of tumor cells, or whether they paradoxically ...

This work concerns the surface modification of iron nitride magnetic nanoparticles by silica encapsulation and subsequent characterization of their magnetic properties. First, we will discuss paragraphs about ε-Fe3N magnetic ...

This work is focused on mixed mode chromatography, a characterisation of 2 mixed mode columns in particular - AcclaimTM WAX-1 and AcclaimTM WCX-1, both of these stationary phases yielding a combination of reversed phase ...

Viruses have long been studied as developmental cofactors for their influence on the development of autoimmune diseases. Among the mechanisms under consideration, viral mechanisms of molecular mimicry, epitope spreading, ...

Ectothermic animals are traditionally regarded as organisms with rather limited ability and need to care for their offspring compared with endothermic animals. This is related to their lower metabolic demands, higher rate ...

Currently, one of the most significant risks to the fishing industry and salmonid fish farming is fish orthoreovirus (PRV) infection. In Europe, the most abundant subtype is currently PRV-3, which mainly attacks rainbow ...

Open mature pine or pine oak forests are home to several rare forest herbs, including the critically endangered wintergreen (Chimaphila umbellata) from the heather family (Ericaceae). This endangered forest herb has its ...