The group of G protein-coupled receptors (GPCRs) represents a large and important family of membrane receptors that transduce extracellular signals into the cell. There are many known types of GPCRs involved in most mediator ...

1 Abstract The presented diploma thesis deals with the laboratory diagnosis of mesotheliomas, rare but aggressive tumors arising from the mesothelium that covers the serous cavities of the body. The aim of the thesis is ...

Epilepsy is the most common chronic neurological disease, affecting approximately 3% of the world's population. It occurs worldwide, affects women and men of all ages and is characterised by recurrent seizures. Sudden ...

Repetitive DNA sequences represent a significant part of the genomes of many eukaryotic organisms. In amphibians, which are characterized by large and variable genomes, repetitive sequences are abundantly present. Amphibians ...

Poikilitic texture has been studied for over six decades and has been observed in both small and large mafic intrusions. Centimeter-sized oikocrysts and the smaller chadacrysts contained within them are the result of ...

The aim of this bachelor's thesis was to design and create a thematic Atlas of defunct villages of the Královský Hvozd in Šumava region. As part of the work, an analysis of the representation of the villages on the maps ...

7 Abstract The aim of this thesis is to propose a method for detecting glacier area changes, with emphasis on distinguishing between false positive changes, such as shadows, surface moisture change, or debris cover on ...

This bachelor thesis focuses on the summary of the current knowledge of neuron navigator proteins (NAVs) in migration of tumor cells. Neuron navigator proteins are cytoskeleton-associated proteins. They interact with ...

Ecological succession is a complex ecological phenomenon studied since the very beginning of ecology as a science. Its course and result can differ significantly with regard to the type of surrounding vegetation, representation ...

As part of education, it is necessary to develop work with a map and the associated map skills, which largely depends on the teachers and their personal concept of teaching. Czech research focuses mainly on teachers of ...

Due to its excellent sealing capabilities, bentonite is considered as an ideal material for sealing a deep underground radioactive waste repository. An integral part of the planned repository is an engineered barrier, which ...

During the very dry period of 2015-2019, several problems with groundwater scarcity emerged, including the drying up of smaller streams in the Czech Republic during dry summer periods. With the intensifying climate change, ...

All organisms maintain a high concentration of potassium cations and a relatively low concentration of sodium cations in their cells, as higher concentrations of sodium cations are toxic to the cells of most organisms. To ...

In this Bachelor's thesis, the synthesis of silicon-containing P-chiral phosphine oxide is reported. The synthesis includes two step alkylation, followed by directed ortho-lithiation and subsequently quenching with an ...

The aim of this work was to analyze the total amount of sterols in pathogenic yeasts of the genus Candida, such as C. albicans, C. glabrata, C. parapsilosis and C. guilliermondii. We established a suitable procedure for ...

The diploma thesis deals with the synthesis of conjugates of the antitumor drug 5- fluorouracil with cyclodextrins. Cyclodextrins are connected to the drug by linkers of different lengths, which are unstable in an acidic ...

This master's thesis is focused on the synthesis of selaginellin T. The work is focused on an identification of suitable protecting groups. It was necessary to prepare a protected substrate for the key [2+2+2] cyclotrimerization ...

Currently, the landscape is being fragmented for example as a result of the construction of transport infrastructure, settlements, and the development of agriculture. This process consists of the gradual disintegration of ...

Acute myeloid leukemia (AML) is a highly heterogeneous group of diseases marked by maturation arrest and rapid growth of undifferentiated myeloid progenitors in the bone marrow and peripheral blood. The advent of next-generation ...

During a typical shallow seismic refraction survey most of the energy is transferred by the surface waves yet most of the time we are only interested in body waves letting approximately 2/3 of the energy go unused while ...

The processes of hybridization and introgression represent one of the most important tools of plant evolution. While these processes carry the risk of extinction for species with small populations or newly established ...

G-protein coupledreceptors(GPCRs) are membrane receptorswitha common structure of seven transmembrane helices. The GPCR superfamily activates complex and significant cellular signalling pathways. GPCRs have high therapeutic ...

Pyrophilous fungi have a relatively unique ecology among fungi, as they have adapted to fire and can thrive in burned areas. Despite the extreme conditions, species that benefit from fire can be found worldwide. Fire ...

Human papillomaviruses (HPV) are small non-enveloped DNA viruses that infect cutaneous and mucosal stratified epithelia. High-risk HPV types (HR-HPV) encode oncoproteins, E6 and E7, that can induce carcinogenesis. Persistent ...

Mountains as bird biodiversity hotspots: Comparison among regions Abstract: Tropical mountain ranges hosting an unusually high number of bird species, often endemic, are considered to be mountain hotspots of bird diversity. ...

Myotubularins are a family of dual-specific phosphatases, divided into two groups, active and inactive enzymes. Active myotubularins recognize and dephosphorylate the phosphoinositides phosphatidylinositol-3-phosphate ...

Endocrine disruptors (EDs) are defined as substances of exogenous origin that disrupt endocrine system. EDs are found in significant amounts in the natural environment, plastic products and flame retardants, leading to ...

The actin cytoskeleton plays a fundamental role in the proper functioning of all eukaryotic cells. It is key in processes such as establishing and maintaining cellular shape, cell division, intracellular transport, and ...

Predicting local structural properties of antibodies at residue level is vital for detecting the presence of post-translational modifications (PTMs), which often induce structural change in the antibody, negatively impact ...

Myelodysplastic neoplasias (MDS) are heterogeneous group of clonal hematopoietic disorders. Chromosome 17 aberrations are one of the rare cytogenetic findings in MDS patients. A cytogenomic analysis of unbalanced aberrations ...