During intrauterine development in mammals, the fetus is exposed to a hypoxic environment. To allow proper postnatal adaptation to external conditions, a rapid transition from glycolytic to oxidative metabolism by mitochondria ...

Inherited disorders of glycosylation (CDG) are a large group of more than 160 types of metabolic disorders caused by genetic defects that lead to impaired glycan biosynthesis and modification. The lipid dolichol plays an ...

Background: Mitragyna Speciosa - a plant, more commonly known as kratom, that has a history and tradition in Southeast Asia for centuries. In recent decades, it has been gaining popularity worldwide. In addition to its ...

The thesis deals with the possibilities of influencing motivation and volition in patients with psychotic illness in occupational therapy. The aim of the thesis is to translate the Volitional Questionnaire and to verify ...

Background: Owing to current demographic trends reflecting an aging population, there is an increase in the group of older individuals facing issues related to alcohol consumption. This group is increasingly seeking ...

9 Abstract: Myelodysplastic syndromes (MDS) are a set of severe hematological diseases characterized by ineffective clonal hematopoiesis in the bone marrow, leading to cytopenia in the peripheral blood, the development of ...

Background: Alcohol use during menopause in women is poorly mapped. Climacterium and the transition from reproductive life to life without menses are associated with many, not only health challenges. Aim: The aim of the ...

Úvod: Nejvýznamnějšími geny spojovanými s hereditárním karcinomem prsu a ovarií jsou BRCA1/2 a vliv na zvýšení rizika se předpokládá též u NBN. Cílem této práce je stanovit frekvenci rekurentních mutací BRCA1/2 v neselektovaném ...

Obezita a s ní spojené komorbidity vedou ke zvýšení rizika mortality. Na tom se významně spolupodílí i rozvoj subklinického zánětu spojený s obezitou. V práci jsme se zaměřili na změny endokrinní a mitochondriální funkce ...

Maisonneuveova zlomenina (MZ) je luxační zlomenina hlezna způsobená zevně rotačním násilím. V tradičním pojetí obsahuje subkapitální zlomeninu fibuly, poranění tibiofibulární syndesmózy a membrana interossea a je považována ...

Prevence v primární péči se zaměřením na screening kolorektálního karcinomu Úvod: Provádění preventivních prohlídek a screeningových metod je nedílnou součástí práce praktického lékaře. Orientuje se především na kardiometabolická ...

Viry svým působením zasáhly vývoj všech organizmů. Mají jednoduchou vnitřní organizaci a obsahují menší množství, většinou dobře popsaných RNA. V případě (+)ssRNA virů slouží genomová RNA rovněž jako mRNA. Díky tomu se ...

Hlavním cílem této práce je podrobný výzkum fluorescenčních nanosond emitujících v blízké infračervené oblasti a jejich využití v biomedicíně. Jsou studovány zejména fluorescenční nanodiamanty (FND) a zlaté nanoklastry ...

Předložená disertační práce se věnuje dvěma hlavním cílům. Jako první byla zkoumána interakce mezi čtyřmi buněčnými liniemi pankreatického duktálního adenokarcinomu (pancreatic ductal adenocarcinoma, PDAC) a kondiciovaných ...

Přední segment oka zahrnuje oční víčka, řasy a slzný film, rohovku, spojivku, duhovku, zornici, řasnaté tělísko, komorový úhel a oční čočku. Katarakta (neboli zákal oční čočky) a dysgeneze předního segmentu oka jsou značně ...

Huntingtonova nemoc (HN) je závažné neurodegenerativní onemocnění s autosomálně dominantní dědičností. HN vzniká následkem expanze CAG tripletu v genu pro protein huntingtin (Htt), která vede k poškození a ztrátě funkcí ...

Obezita je chronické onemocnění, které je podmíněno mnoha faktory. Nadměrné zmnožení tukové tkáně se podílí na rozvoji řady metabolických a kardiovaskulárních onemocnění. K léčbě obezity a prevenci kardiometabolických rizik ...

Tato dizertační práce zkoumá vztah mezi stravou, střevní mikrobiotou a metabolickým zdravím. Konkrétně se zaměřuje na vztah mezi složením střevní mikrobioty a nepřenosnými metabolickými chorobami, jako je obezita a diabetes ...

This doctoral thesis pictures neurodegenerative diseases as a multilevel process, describes various correlates on each pathophysiological level, and presents selected correlates in Huntington's disease and mitochondrial ...

Neurological manifestations of Fabry disease Abstract The presented thesis deals with cerebrovascular manifestations of a rare X-linked disease, Fabry disease (FD). Screening programs can detect unrecognized disease and ...

Introduction: Achalasia is a primary motility disorder of the esophagus due to degeneration neurons in myenteric plexus. Although the exact pathogenesis is unknown, autoimmune and neurodegenerative processes seem to be ...

Background: The nightlife environment is associated with a higher prevalence of substance use compared to the general population. This use is typically recreational. Patterns of use, frequency and motivation tend to be ...

Baseline: Self-esteem is often perceived as an indicator of emotional and mental well-being and life satisfaction. How we perceive ourselves is also important for our environment. Addiction disrupts the attitude towards ...

Title: The Role of an Occupational Therapist in Supporting Functional Communication for People with Expressive Aphasia Abstract: The bachelor thesis is theoretical and practical. The aim of the bachelor thesis is to find ...

Background: In the addiction treatment continuum, there is a relatively large group of clients with a dual diagnosis who repeatedly fail in treatment and follow-up treatment, with frequent relapses and recurrences of the ...

Multiple sclerosis (MS) is a chronic neurological disease that, without treatment, leads over years to decades to severe disability in most patients. We cannot cure the disease, but there is growing evidence that early ...

1 Food allergies in children are common (affecting up to 8% of children) and their prevalence has been increasing in the last two to three decades. The basic measure for the long-term management of food allergy is an ...

Bisphenol A (BPA) is an endocrine disruptor that may be released from dental polymeric materials. The aim of this study was to examine the kinetics of the long-term release of BPA and its analogues from restorative materials ...

Fractures of the scapula used to be among rare injuries, but in the last two decades their number has increased. Fractures of the scapula can be isolated, but in 67-92% they are combined with injuries to other structures ...

Background: Drug consumption rooms are a service where clients can consume illegal addictive substances under the supervision of trained staff. In some countries, drug consumption rooms have been in operation for over 30 ...

Background: Psychiatric comorbidity means the concurrence of an addiction diagnosis with one or more psychiatric diagnoses in a given individual. Psychiatric comorbidities are one of the frequent complications not only in ...

Background: In the last few years, a large number of nicotine products have appeared on the Czech market, which are intended, among other things, to serve as alternatives to conventional cigarettes. These alternatives are ...

Background: Cigarette smoking is one of the main causes of high mortality and morbidity rates in addiction patients. The prevalence of smoking among patients in addiction treatment is many times higher than in the general ...

Background: The topic of crime is interconnected with substance abuse users. While most studies and statistics focus on primary criminal activities and economically motivated crimes, the chapter on criminal activities ...

Background: "A stroke is a brain disease caused by a sudden vascular supply malfunction" (Růžička, 2019, p. 213) and "nn the Czech Republic, it affects more than 50,000 people every year" (Zámečník et al., 2019, p. 676). ...

Drop-in center Vlhká, operated by the organization Podané ruce, implements the Managed Alcohol Program as the only organization in the Czech Republic, inspired by similar programs abroad. In this work, I utilize satisfaction ...

Background: During adolescence, individuals develop their own lifestyle, experience self- awareness, and shape their identity. Children in this period often experiment, reject advice, and disregard the opinions of adults. ...

Background: Psychedelics are substances that affect the nervous system and have the ability to influence thinking, perception and feelings of the user. In the Czech Republic, psilocybe mushrooms are the second most used ...

Introduction: A relatively new trend that has been gaining popularity in recent years is heated tobacco, which has been on the Czech market since 2017. Although the number of users of heated tobacco products in the Czech ...

The thesis deals with the dietary habits of schizophrenic patients and the effect of anti- inflammatory food on the levels of inflammatory markers in the blood. Patients suffering from schizophrenia are observed to have ...