This theoretical-research bachelor thesis focuses on the impact of barefoot walking on the musculoskeletal system from a physiotherapy perspective. The theoretical part of the thesis presents a current overview of the issue ...

Náš výzkum byl zaměřen na novou metodu transplantace Langerhansových ostrůvků do velkého omenta. Transplantace Langerhansových ostrůvků je zavedenou možností léčby vybraných pacientů s nestabilním diabetem. Jako místo pro ...

Introduction: Thrombophilic conditions may be accompanied by increased thrombin generation (TG), especially during pregnancy when the increase in thrombin generation results from a series of changes in the haemostatic ...

The disease diabetes mellitus is reaching an alarming level worldwide and its prevalence is rising sharply every year. The Czech Republic has over a million patients with this disease. This is a major societal problem, ...

Over the past decade, scientific research has focused on the intricate relationship between the human microbiome and the immune system. A particular emphasis in the last three years has been on investigating the impact of ...

This bachelor's thesis discusses the issue of gestational diabetes and the influence of the diagnosis on nutrition and exercise/sport in diagnosed women. The theoretical part discusses the pathogenesis of GDM, risk factors ...

Palliative care is an approach focused on improving or maintaining quality of life for patients and their families who suffer from terminal illness in an advanced stage. Hospices are most commonly associated with palliative ...

The topic of this bachelor thesis is the issue of nutritionally important components of fish muscle in the prevention of serious diseases. Fish meat is a rich source of essential amino acids, polyunsaturated fatty acids, ...

The obesity epidemic is still a very topical problem and requires a comprehensive therapy that includes nutritional counselling. In my practical experience, the topic of protein and fibre tends to be very common with obese ...

EN The objective of this work was to study novel synthetic iron chelators and to study their potential use in inhibition of TET1 (ten-eleven translocation methylcytosine dioxygenase 1) protein. Epigenetic mechanisms, such ...

In my dissertation, I studied the genetic predisposition of selected types of cancer that have not been systematically studied in the Czech Republic. We used next-generation panel sequencing to identify germline pathogenic ...

Thin fibrous cap atheroma with a high lipid content is the most common morphological substrate for acute coronary syndrome. Lipid content can be reliably determined by near infrared spectroscopy (NIRS) imaging. Optical ...

Steroid hormones can be divided into 2 groups - intracellular and extracellular, depending on location of their activity. Intracellular ones influence expression of genes while acting as transcription factors. This so-called ...

Background: In Czech Republic, the use of addictive substances in the general population is regularly evaluated. In people with spinal cord lesions, the issue of substance abuse is not sufficiently mapped. Difficulty to ...

BACHELOR THESIS ABSTRAKT Name, Surname: Jana Račanová Supervisor: Bc. Zuzana Rodová M.Sc. Title: Instruments for evaluation of the structure of the day in the occupational therapy Abstract: The bachelor thesis is ...

The dissertation evaluates the results of a first metatarsophalangeal (MTP) joint replacement. The PH-Flex MTP joint replacement was developed at the 1st Department of Orthopaedics, the first faculty of medicine in conjunction ...

Background: Understanding patterns of use and the needs of young adult users of illegal addictive substances presents a challenge primarily due to the hidden nature of this problem. Individuals engaging in problem drug use ...

Background: Human needs encompass a spectrum ranging from fundamental physiological requirements, such as breathing and sustenance, to elevated needs like love and appreciation. While most individuals fulfill these needs ...

Background: Music is an essential part of human life. Substance use is often associated with music artists, but research has shown that the risk extends to their listeners. Studies show that the genres at risk include rock, ...

Purines are involved in many biologic processes and are required to maintain stable energy charge, for metabolic regulation, as cofactors in enzymatic reactions and as building blocks in DNA and RNA. Necessary role in ...

During intrauterine development in mammals, the fetus is exposed to a hypoxic environment. To allow proper postnatal adaptation to external conditions, a rapid transition from glycolytic to oxidative metabolism by mitochondria ...

Inherited disorders of glycosylation (CDG) are a large group of more than 160 types of metabolic disorders caused by genetic defects that lead to impaired glycan biosynthesis and modification. The lipid dolichol plays an ...

Background: Mitragyna Speciosa - a plant, more commonly known as kratom, that has a history and tradition in Southeast Asia for centuries. In recent decades, it has been gaining popularity worldwide. In addition to its ...

The thesis deals with the possibilities of influencing motivation and volition in patients with psychotic illness in occupational therapy. The aim of the thesis is to translate the Volitional Questionnaire and to verify ...

Background: Owing to current demographic trends reflecting an aging population, there is an increase in the group of older individuals facing issues related to alcohol consumption. This group is increasingly seeking ...

9 Abstract: Myelodysplastic syndromes (MDS) are a set of severe hematological diseases characterized by ineffective clonal hematopoiesis in the bone marrow, leading to cytopenia in the peripheral blood, the development of ...

Background: Alcohol use during menopause in women is poorly mapped. Climacterium and the transition from reproductive life to life without menses are associated with many, not only health challenges. Aim: The aim of the ...

Úvod: Nejvýznamnějšími geny spojovanými s hereditárním karcinomem prsu a ovarií jsou BRCA1/2 a vliv na zvýšení rizika se předpokládá též u NBN. Cílem této práce je stanovit frekvenci rekurentních mutací BRCA1/2 v neselektovaném ...

Obezita a s ní spojené komorbidity vedou ke zvýšení rizika mortality. Na tom se významně spolupodílí i rozvoj subklinického zánětu spojený s obezitou. V práci jsme se zaměřili na změny endokrinní a mitochondriální funkce ...

Maisonneuveova zlomenina (MZ) je luxační zlomenina hlezna způsobená zevně rotačním násilím. V tradičním pojetí obsahuje subkapitální zlomeninu fibuly, poranění tibiofibulární syndesmózy a membrana interossea a je považována ...

Prevence v primární péči se zaměřením na screening kolorektálního karcinomu Úvod: Provádění preventivních prohlídek a screeningových metod je nedílnou součástí práce praktického lékaře. Orientuje se především na kardiometabolická ...

Viry svým působením zasáhly vývoj všech organizmů. Mají jednoduchou vnitřní organizaci a obsahují menší množství, většinou dobře popsaných RNA. V případě (+)ssRNA virů slouží genomová RNA rovněž jako mRNA. Díky tomu se ...

Hlavním cílem této práce je podrobný výzkum fluorescenčních nanosond emitujících v blízké infračervené oblasti a jejich využití v biomedicíně. Jsou studovány zejména fluorescenční nanodiamanty (FND) a zlaté nanoklastry ...

Předložená disertační práce se věnuje dvěma hlavním cílům. Jako první byla zkoumána interakce mezi čtyřmi buněčnými liniemi pankreatického duktálního adenokarcinomu (pancreatic ductal adenocarcinoma, PDAC) a kondiciovaných ...

Přední segment oka zahrnuje oční víčka, řasy a slzný film, rohovku, spojivku, duhovku, zornici, řasnaté tělísko, komorový úhel a oční čočku. Katarakta (neboli zákal oční čočky) a dysgeneze předního segmentu oka jsou značně ...

Huntingtonova nemoc (HN) je závažné neurodegenerativní onemocnění s autosomálně dominantní dědičností. HN vzniká následkem expanze CAG tripletu v genu pro protein huntingtin (Htt), která vede k poškození a ztrátě funkcí ...

Obezita je chronické onemocnění, které je podmíněno mnoha faktory. Nadměrné zmnožení tukové tkáně se podílí na rozvoji řady metabolických a kardiovaskulárních onemocnění. K léčbě obezity a prevenci kardiometabolických rizik ...

Tato dizertační práce zkoumá vztah mezi stravou, střevní mikrobiotou a metabolickým zdravím. Konkrétně se zaměřuje na vztah mezi složením střevní mikrobioty a nepřenosnými metabolickými chorobami, jako je obezita a diabetes ...

This doctoral thesis pictures neurodegenerative diseases as a multilevel process, describes various correlates on each pathophysiological level, and presents selected correlates in Huntington's disease and mitochondrial ...

Neurological manifestations of Fabry disease Abstract The presented thesis deals with cerebrovascular manifestations of a rare X-linked disease, Fabry disease (FD). Screening programs can detect unrecognized disease and ...

Introduction: Achalasia is a primary motility disorder of the esophagus due to degeneration neurons in myenteric plexus. Although the exact pathogenesis is unknown, autoimmune and neurodegenerative processes seem to be ...

Background: The nightlife environment is associated with a higher prevalence of substance use compared to the general population. This use is typically recreational. Patterns of use, frequency and motivation tend to be ...

Baseline: Self-esteem is often perceived as an indicator of emotional and mental well-being and life satisfaction. How we perceive ourselves is also important for our environment. Addiction disrupts the attitude towards ...

Title: The Role of an Occupational Therapist in Supporting Functional Communication for People with Expressive Aphasia Abstract: The bachelor thesis is theoretical and practical. The aim of the bachelor thesis is to find ...

Background: In the addiction treatment continuum, there is a relatively large group of clients with a dual diagnosis who repeatedly fail in treatment and follow-up treatment, with frequent relapses and recurrences of the ...

Multiple sclerosis (MS) is a chronic neurological disease that, without treatment, leads over years to decades to severe disability in most patients. We cannot cure the disease, but there is growing evidence that early ...

1 Food allergies in children are common (affecting up to 8% of children) and their prevalence has been increasing in the last two to three decades. The basic measure for the long-term management of food allergy is an ...

Bisphenol A (BPA) is an endocrine disruptor that may be released from dental polymeric materials. The aim of this study was to examine the kinetics of the long-term release of BPA and its analogues from restorative materials ...

Fractures of the scapula used to be among rare injuries, but in the last two decades their number has increased. Fractures of the scapula can be isolated, but in 67-92% they are combined with injuries to other structures ...

Background: Drug consumption rooms are a service where clients can consume illegal addictive substances under the supervision of trained staff. In some countries, drug consumption rooms have been in operation for over 30 ...