Cíle: Cílem této diplomové práce bylo porovnat podíl příčin náhlých srdečních zástav v závislosti na věku, zkoumat podíl kardiálních náhlých srdečních zástav v závislosti na pohlaví a analyzovat vliv věku na pravděpodobnost ...

Aktivace N-methyl-D-aspartátového receptoru (NMDAR) vede skrze intracelulární signální kaskády k modulaci funkční a strukturní plasticity, a sehrává tak zásadní roli v kognitivních procesech jako je učení a paměť. Poruchy ...

Background: One of the most common clinical manifestations of multiple sclerosis is foot drop syndrome, which significantly affects the gait and balance of people with multiple sclerosis (MS). Functional electrical stimulation ...

1 ABSTRACT Introduction: The incidence of head and neck squamous cell carcinoma (HNSCC) is on a continuous increasing trend worldwide, despite known risk factors and primary prevention of the disease. Secondary prevention ...

Background: Considerable number of patients suffering from depression (unipolar or bipolar) does not reach a relief undergoing pharmacological or psychotherapeutic treatments available. There is a need for a new treatment ...

A randomized comparison of His bundle pacing versus RV pacing: effect on left ventricular function and biomarkers of collagen metabolism Background: Right ventricular pacing (RVP) may result in pacing-induced cardiomyopathy ...

1 SUMMARY Obesity and overfeeding are associated not only with increased circulating levels of nutrients and metabolites, but also with increased risk of the development of additional disorders, such as cardiovascular ...

Acute leukemias (AL) comprise a heterogeneous group of hematologic malignancies, and individual patient responses to treatment can be difficult to predict. Monitoring of minimal residual disease (MRD) is thus very important ...

This project has shown that pelvic organ prolapse is linked with maternal age and delivery-related injuries. Up to every eight women may have a symptomatic prolapse already one year after their first delivery. Moreover, ...

Keywords Burn shock; fluid therapy; arterial pulse contour analysis; dynamic preload parameters; hourly urine output. Introduction: Our hypothesis is based on the assumption that ...

Preterm neonate is exposed to significant hemodynamic changes after delivery. Cardiac and extracardiac shunts, especially ductus arteriosus, play an important role in this process. Failure of postnatal adaptation and ...

Intraarticular bleeding is a complication, that concerns almost every person with haemophilia. The number and heaviness of them depends on the grade of illness and on presence of inhibitor. Presence of blood inside joint ...

Background. The analysis of the current approaches to antithrombotic treatment of cardiac patients in the perioperative period of major non-cardiac surgery was performed. The incidence of ischemic and bleeding complications ...

Adipose tissue (AT) is a complex organ specialised in safe storage and release of energy as lipids. The adipose organ is therefore essential for the maintenance of energy homeostasis. The prototypical cells of AT are ...

Obstetrical brachial plexus palsy (OBPP) displays a stable incidence of 0.15 - 3 per 1,000 live births. Most children show good spontaneous recovery, but a recent literature reviews show that a residual deficit remains in ...

The alternation of light and darkness,caused by the Earth's rotation around its axis, is one of the significant factorsinfluencing life on our planet. This cycle is so fundamental that it has affectedthe evolutionary ...

This Thesis discusses the complex topic of the role of proteinase-activated receptors (PARs) in the physiology and pathophysiology of central nervous system diseases, and to some extent, the role of PARs in cancer pathobiology. ...

The dissertation is focused on the problem of visual perception and its dis- turbance in patients with schizophrenia. The relationship between dopaminergic transmission at the retinal level and its possible association ...

Breast carcinoma is the most common cancer among women in our country and worldwide. One of the obstacles to successful therapy is a multidrug resistance. It can be caused by different factors, such as overexpression of ...

BACKGROUND: ICU-acquired weakness impairs functional outcome in survivors of critical illness. Therefore, deepening our understanding of its pathogenesis is an important goal as muscle-specific therapeutic targets are ...

Changes in the regulation of apoptosis and cell cycle are involved in tumor development, progression, and resistance to antitumor therapy. The aim of this work was to evaluate the importance of apoptotic caspases and ...

Possibilities of prevention reflecting geriatric principles: Functional status and depressivity in old age Hana Vaňková, MD Abstract Background: Given the population ageing in Europe and in the Czech Republic, strategies ...

Remarkable progress in therapy and diagnostics of neurological diseases, including brain and spinal cord injuries, has been achieved during last years. However, the nervous system with its complicated feedback circuits ...

Iron belongs among the trace elements and its role in humans is irreplaceable. Up to 5 g of iron can be found in adult body distributed among different compounds. Iron ions are therefore essential to all cells of our body ...

Islet cell autoantibodies are associated with autoimmune insulitis and belong to the diagnostic criteria of Type 1 diabetes mellitus. However, growing evidence suggests that autoantibodies are present in other types of ...

Nutritional Factors in Skeletal Muscle Insulin Resistance Development Jan Gojda Abstract Background. Diet composition ranks among etiological factors of insulin resistance (IR) and diabetes. Vegans, people consuming ...

Skeletal muscle is the largest tissue in the body and plays a marked role in the homeostasis of the body metabolic state. Mitochondria have been proven to contribute to the pathophysiology of various metabolic diseases, ...

Title: "Optimization Approach to the Detection of Sentinel Node in Endometrial Cancer." Design: prospective experimental study Aim of thesis : The purpose of this study was to evaluate predictive value of the in vivo ...

The aim was to document the trend in pertussis in the Czech Republic (CR) with regard to the infant population under one year of age, which is at highest risk for pertussis. Another point was to answer two questions: 1) ...

SUTORIS, Karol. Fotodynamická terapie xenotransplantovaných lidských tumorů. [Photodynamic therapy of xenotransplanted human tumours]. Prague, 2015. 168 pp. Doctoral Thesis. Charles University in Prague, Third Faculty of ...

Unusual aspects of valvular heart disease - the role of noninvasive imaging methods MUDr. Hana Línková Abstract More than 100 million people around the word suffer from valvular heart diseases (VHD). We observe changes in ...

Ventilator-associated pneumonia (VAP) is the most common hospital- acquired infection in intensive care units. It develops more than 48 hours after the patient is connected to mechanical ventilation. It is a serious infection ...

Bakalářská práce se zabývá výživou pacientů s karcinomem pankreatu s důrazem na příjem bílkovin. Zároveň zkoumá souvislosti mezi dostatečnou/nedostatečnou výživou a kvalitou života pacienta, případě celkovým vývojem jeho ...

Cílem této práce bylo srovnání vizualizačního tréninku, tradičního tréninku sportovně specifických dovedností a kondičního tréninku pomocí Loughborough soccer passing testu, zaměřeném na hodnocení kvality přihrávky. Metodika ...